Lipids: Triglycerides & Phospholipids

This lesson covers:

  1. The structure and function of triglycerides 
  2. The synthesis and breakdown of triglycerides 
  3. The structure and function of phospholipids
  4. The similarities and differences between triglycerides and phospholipids

Triglycerides

A triglyceride is a type of lipid used as a store of energy in animals, plants, and some bacteria.

Diagram showing the structure of a triglyceride with a glycerol backbone and three fatty acid tails.

The left diagram is a simplified version of a triglyceride. The diagram on the right shows the atoms a triglyceride is made up of. 


A triglyceride consists of a glycerol backbone attached to three fatty acid tails. Each fatty acid tail contains a hydrocarbon chain (R) which can vary in length and may be saturated or unsaturated.

Features that allow triglycerides to store energy efficiently: 

  1. Long hydrocarbon tails - Their many carbon-hydrogen bonds can be broken to release energy.
  2. Low mass to energy ratio - Lots of energy can be stored in a small volume.
  3. Insoluble - They do not affect the water potential of cells as they are large and polar.
  4. High ratio of hydrogen to oxygen atoms - Triglycerides will release water when oxidised.

Triglyceride formation and breakdown

Triglycerides are synthesised via condensation reactions and broken down via hydrolysis reactions. These reactions involve the formation or the breakdown of covalent bonds known as ester bonds.

Condensation reaction

Diagram showing the condensation reaction forming triglycerides from glycerol and fatty acids, and the hydrolysis reaction breaking ester bonds.

Condensation:

  • The hydroxyl groups (OH) on the glycerol and on the three fatty acids react together to release three water molecules (H2O).
  • This results in three ester bonds between the glycerol and the fatty acids.

Hydrolysis reaction 

Diagram showing the formation and breakdown of triglycerides, highlighting ester bonds, hydrolysis, and condensation reactions.

Hydrolysis:

  • The addition of three water molecules (H2O) breaks the ester bonds.
  • This separates the glycerol and the fatty acids.

Phospholipids

A phospholipid is a type of lipid used as a structural component of the cell membrane. 

Diagram showing the structure of a phospholipid with a phosphate group, glycerol, and two fatty acid tails.

They are similar to triglycerides except one of the fatty acid tails is replaced by a phosphate group.

Phospholipids are polar 

A phospholipid is made up of two parts: 

  1. A hydrophilic 'head' - This contains glycerol and phosphate.
  2. A hydrophobic 'tail' - This contains fatty acids.

Diagram showing the structure of a phospholipid with a hydrophilic head containing glycerol and phosphate and a hydrophobic tail containing fatty acid.

The phosphate group is polar and so attracts water (hydrophilic) whereas the fatty acid tails repel water (hydrophobic).

Phospholipid bilayer 

When phospholipids are placed in water, they arrange themselves into a double layer (bilayer) so that the hydrophilic heads are facing out (towards the water) and the hydrophobic tails are facing in (away from the water). 

Diagram showing the arrangement of phospholipids in a bilayer with hydrophilic heads facing outwards and hydrophobic tails facing inwards.

This arrangement creates a hydrophobic centre in the bilayer so that water-soluble substances cannot pass through.

Comparing triglycerides and phospholipids 

Comparison table showing the differences between triglycerides and phospholipids, including function, number of fatty acid tails, presence of phosphate, and polarity.