Welcome to the Quiz!
This quiz contains 10 questions from a mix of 1 subtopics.
What is the central metal ion in cisplatin?
nickel(II)
palladium(II)
platinum(IV)
platinum(II)
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What is the geometric arrangement of ligands around the central platinum ion in cisplatin?
tetrahedral
square planar
linear
octahedral
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How does cisplatin bind to DNA in cancer cells?
through ligand substitution reactions
through ionic bonding
through hydrogen bonding
through induced dipole-dipole forces
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Which DNA base does cisplatin primarily form coordinate bonds with?
adenine
guanine
thymine
cytosine
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How many guanine bases does a single cisplatin complex ion typically bind to in the DNA double helix?
3
1
4
2
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What is the effect of cisplatin binding to DNA in cancer cells?
it hinders DNA replication
it has no effect on DNA replication
it enhances DNA repair mechanisms
it promotes DNA replication
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Which of the following best describes the binding of cisplatin to DNA?
crosslinking between a guanine base and an adenine base
crosslinking between a guanine base and a thymine base
crosslinking between two guanine bases on opposite DNA strands
crosslinking between two guanine bases on the same DNA strand
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What effect does cisplatin binding have on the structure of DNA?
it causes kinks in the DNA structure
it causes the DNA to unwind
it straightens the DNA helix
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Why is cisplatin an effective anti-cancer drug?
it prevents cancer cells from multiplying
it repairs damaged DNA in cancer cells
it enhances the immune system's response to cancer cells
it promotes cancer cell growth
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Why is the dosage of cisplatin kept low during cancer treatment?
to prevent drug resistance
to maximise its effectiveness
to minimise side effects
to reduce treatment costs
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