What is the humoral response?

The humoral response is a specific defence mechanism involving the production of antibodies to destroy pathogens.

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What are B lymphocytes?

B lymphocytes, or B cells, are cells involved in the humoral response that are covered in antibodies.

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Which process activates the division of B cells?

Helper T cells bind to antigen-presenting B cells to activate B cell division.

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What do plasma cells do?

Plasma cells produce and secrete antibodies against a specific antigen.

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What is the function of memory cells?

Memory cells provide long-term immunity and rapidly divide into plasma cells that produce antibodies specific to a pathogen's antigens on reinfection.

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Why is the humoral response described as 'humoral'?

It is described as humoral because it involves antibodies found in body fluids (or humor).

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What is the role of B cells in the humoral response?

  1. B cells with complementary antibodies bind to a pathogen's antigens, engulf them, and present them on their cell-surface membrane.
  2. B cells are then activated by a T helper cell binding to these antigens.
  3. On activation, B cells divide by mitosis to form plasma cells and memory cells. 

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What is the role of T cells in the humoral response? 

T helper cells bind to B cells with complementary antibodies to the pathogen's antigens to activate their division

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What is clonal selection?

The process of selecting B cells with the correct antibody for cloning.

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What happens during the primary immune response?

During the primary immune response, the concentration of antibodies increases slowly as B cells divide into plasma cells, which produce antibodies, and some divide into memory cells.

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What happens during the secondary immune response?

During the secondary immune response, the concentration of antibodies increases quickly as memory cells recognise the pathogen's antigens and divide into plasma cells.

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